Table 2.
GWAS summary statistics: source and description.
| Type | Phenotype | Data source | Sample | Ethnicity |
|---|---|---|---|---|
| Exposure | PM2.5 | UK Biobank/ ESCAPE | 423,796 | European |
| Outcome | Longevity | Longevity Genomics research group | 11,262/3,484 cases and 25,483 controls | European, East Asian, and African American |
| Potential confounders | nitrogen dioxide air pollution | UK Biobank/ ESCAPE | 456,380 | European |
| nitrogen oxides air pollution | UK Biobank/ ESCAPE | 456,380 | European | |
| PM10 | UK Biobank/ ESCAPE | 423,796 | European | |
| PM2.5-10 | UK Biobank/ ESCAPE | 423,796 | European | |
| cigarettes smoked per day | GSCAN | 337,334 | European | |
| Potential mediators | BMI | GIANT | 693,529 | European |
| WHR | GIANT | 693,529 | European | |
| HC | GIANT | 142,762 | European | |
| WC | GIANT | 142,762 | European | |
| T1D | CMDKP | 9,358 cases/15,705 controls | European | |
| T2D | DIAMANTE | 80,154 cases /853,816 controls | European | |
| FG, FI, HbA1c | GWAS Catalog | 281,416 | European | |
| LDL-C | UK Biobank, Global Lipids Genetics Consortium | 431,167 | European | |
| Hypercholesterolaemia | UK Biobank | 22,622 cases/440,388 controls | European | |
| DBP | ICBP | 757,601 | European | |
| SBP | ICBP | 757,601 | European | |
| Hypertension | UK Biobank | 2095 cases/460,838 controls | European | |
| CAD | CMDKP | 86,847 cases/417,789 controls | European | |
| Angina pectoris | UK Biobank | 4256 cases/458,754 controls | European | |
| HF | HERMES | 47,309 cases/930,014 controls | European | |
| AF | CMDKP | 55,114 cases/482,295 controls | European | |
| IHD | UK Biobank | 1195 cases/461,815 controls | European | |
| Stroke | GWAS Catalog | 73,652 cases/1,234,808 controls | European | |
| IS | GWAS Catalog | 62,100 cases/1,234,808 controls | European | |
| FVC | SpiroMeta Consortium, UK Biobank | 321,047 | European | |
| FEV1/FVC | SpiroMeta Consortium, UK Biobank | 321,047 | European | |
| COPD | UK Biobank, COPDGene Study, SpiroMeta Consortium | 21,077 cases/179,689 controls | European | |
| Lung cancer | ILCCO | 11,348 cases/15,861 controls | European | |
| Asthma | UK Biobank | 1877 cases/461,133 controls | European | |
| Hypothyroidism | UK Biobank | 22,687 cases/440,246 controls | European | |
| SLE | GWAS Catalog | 7219 cases/15,991 controls | European | |
| CD | IIBDGC | 17,897 cases/33,977 controls | European | |
| UC | IIBDGC | 13,768 cases/33,977 controls | European | |
| RA | GWAS Catalog | 14,361 cases/43,923 controls | European | |
| MS | IMSGC | 47,429 cases/68,374 controls | European | |
| ALS | GWAS Catalog | 20,806 cases/59,804 controls | European | |
| PD | IPDGC | 33,674 cases/449,056 controls | European | |
| AD | UK Biobank, IGAP | 75,024 cases/397,844 controls | European | |
| LBD | GWAS Catalog | 2981 cases/4,391 controls | European |
AD Alzheimer’s disease, AF atrial fibrillation, ALS amyotrophic lateral sclerosis, BMI body mass index, CAD coronary artery disease, CD Crohn’s disease, COPD chronic obstructive pulmonary disease, DBP diastolic blood pressure, FEV1/FVC 1 s forced expiratory volume/FVC, FG fasting glucose, FI fasting insulin, FVC forced vital capacity, HbA1c glycated hemoglobin, HC hip circumference, HF heart failure, IHD ischemic heart disease, IS ischemic stroke, LBD lewy body dementia, MS multiple sclerosis, PD Parkinson’s disease, RA rheumatoid arthritis, SBP systolic blood pressure, SLE Systemic lupus erythematosus, T1D type 1 diabetes, T2D type 2 diabetes, UC Ulcerative colitis, WC waist circumference, WHR waist-hip ratio.