Fig. 1.

Schematic of PEDV inhibitors screening from a natural product library. Vero cells were pre-treated with natural compounds or 0.1 % DMSO for 4 h, and then infected with DR13-GFP in the presence of compounds. The CPE was observed and recorded at 12, 24 and 36 hpi, scale bars = 150 μm. (A) Diagram of the initial antiviral screening model. (B) Ten drugs, including Oleanolic acid (1–10), Moxidectin (1–17), Octyl gallate (1–71), 1,2,3,4,6-Pentagalloylglucose (1–74), Theaflavin 3,3′- digallate (2–2), Curcumin (2–4), Baicalin (3–10), Xanthohumol (3–11), Tubercidin (3–19), Rubitecan (3–25), displayed inhibitory effects on PEDV DR13-GFP infection. (C) PEDV replication inhibition rates after treatment. The blue dot represents the natural compounds with effective antiviral activity, while the red dot represents Tubercidin.