Fig. 2.

Distribution of life-time breast cancer risk in CHEK2 c.1100del carriers (A) and non-carriers (B) calculated using BOADICEA version 6 with stepwise inclusion of risk factors. The background of the graphs are shaded indicating the Dutch lifetime breast cancer risk categories for women [8]: red = population risk (≤20 %); yellow = moderate risk (>20 % and <30 %); blue = high risk (≥30 %). The vertical purple line indicates the average life-time breast cancer risks for the Dutch population the vertical red line that for CHEK2 c.1100delC heterozygotes.

FH = family history; QRF = questionnaire-based risk factors; PRS = polygenic risk score based on 311 variants; BD = breast density based on BIRADS