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. 2023 Dec 19;14:8437. doi: 10.1038/s41467-023-43614-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Cell viability assay in MM.1S and CRBN KO MM.1S cell lines for 96 h at different concentrations. sgRNAs targeting luciferase (Luc1 and Luc2) are used as control. Graph bars represent mean values ± SD. n = 3 independent biological replicates. B Immunoblot analysis for neo-substrates in the MM.1S and CRBN KO MM.1S cell lines treated with H7, K11, and E14 for 18 h. sgRNAs targeting luciferase (Luc1 and Luc2) are used as control. The experiment was repeated three times independently with similar results. Source data are provided as a Source Data file.