Table 3.

Distinguishing features of mast cell vs. bradykinin-mediated angioedema.

	Bradykinin-mediated	Mast cell-mediated
Duration	Slow onset and resolution (usually days)	Rapid onset and resolution (usually minutes to hours)
Concomitant hives	No	Often
Gastrointestinal involvement	Yes, bowel edema leading to obstruction	Uncommon, although possible in anaphylaxis
Respiratory involvement	Yes, due to laryngeal edema	Uncommon, although possible in anaphylaxis
Family history	Yes, in hereditary angioedema	No
Response to adrenaline, H1 antihistamines, corticosteroids, or omalizumab	No	Yes
Response to icatibant or other bradykinin-targeted medications	Yes	No