Table 6.

Results of tests for heterogeneity and pleiotropy in exposure (HDL-C, LDL-C and TC) to mediators.

	HDL-C				LDL-C				TC
	Heterogeneity		Pleiotropy		Heterogeneity		Pleiotropy		Heterogeneity		Pleiotropy
	Q	p	Intercept	p	Q	p	Intercept	p	Q	p	Intercept	p
SBP	1108.588	5.20E-83	-0.004	0.510	823.663	1.05E-54	0.003	0.691	918.049	2.04E-56	-0.003	0.664
PR	610.292	2.94E-07	-5.88E-05	0.873	516.224	1.42E-07	5.38E-04	0.242	587.284	6.50E-08	2.91E-04	0.501
HC	294.370	7.81E-09	-7.19E-04	0.312	163.089	7.95E-02	1.84E-04	0.828	176.940	4.14E-02	-4.10E-04	0.601
WC	245.613	1.93E-03	-2.08E-03	6.28E-04	167.892	6.8E-02	4.78E-04	0.556	173.099	8.61E-02	8.28E-04	0.256
WHR	230.451	2.68E-03	-0.001	0.027	209.770	1.89E-04	0.001	0.138	194.717	9.52E-03	0.001	0.098
BMI	341.203	5.00E-24	-9.10E-04	0.041	292.189	2.48E-19	3.01E-05	0.959	300.112	6.83E-19	-2.58E-04	0.626
L-HGS	1122.595	1.32E-58	-7.83E-05	0.743	752.171	2.2E-29	2.96E-05	0.913	870.828	2.14E-33	-2.28E-04	0.362
R-HGS	1104.712	1.70E-56	-3.58E-04	0.131	786.854	4.80E-33	1.82E-05	0.947	880.115	1.31E-34	-2.81E-04	0.284
Fasting glucose	134.192	0.431	-3.15E-05	0.517	135.433	0.024	6.93E-04	0.397	81.158	0.988	4.86E-04	0.464