Table 2.
Clinical characteristics of COVID-19 patients with different viral strains infection.
| Wild-type (n = 247) | Alpha (n = 13) | Beta (n = 18) | Delta (n = 35) | Omicron (n = 119) | F/H/Chi-square | P value | |
|---|---|---|---|---|---|---|---|
| Age | 45.00(34.00–59.00) | 35.00(29.50–50.00) | 41.00(34.00–47.00) | 38.00(30.00–48.00) | 43.00(33.00–52.00) | 8.980 | 0.062 |
| Gender | 47.55 | <0.001 | |||||
| Males | 126(51.0)a | 11(84.6) | 16(88.9) | 32(91.4) | 92(77.3) | ||
| Females | 121(49.0) | 2(15.4) | 2(11.1) | 3(8.6) | 27(22.7) | ||
| Vaccination | 26.86 | <0.001 | |||||
| Inoculated | 0(0.0)a | 0(0.0)b | 4(22.2)c | 32(91.4) | 116(97.5) | ||
| Uninoculated | 247(100.0) | 13(100.0) | 14(77.8) | 3(8.6) | 3(2.5) | ||
| Number of vaccination doses | |||||||
| 0 | 245(99.2) | 13(100.0) | 14(77.8) | 3(8.6) | 3(2.5) | ||
| 1 | 0(0.0) | 0(0.0) | 0(0.00) | 3(8.6) | 4(3.4) | ||
| 2 | 0(0.0) | 0(0.0) | 4(22.2) | 28(80.0) | 65(54.6) | ||
| 3 | 0(0.0) | 0(0.0) | 0(0.0) | 1(2.8) | 38(31.9) | ||
| 4 | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 9(7.6) | ||
| Missing data | 2(0.8) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | ||
| Unvaccinated | 245(99.2) | 13(100.0) | 14(77.8) | 3(8.6) | 3(2.5) | ||
| Vaccination type | |||||||
| Sinopharm | 0(0.0) | 0(0.0) | 3(16.7) | 24(68.6) | 34(28.6) | ||
| Sinovac-CoronaVac | 0(0.0) | 0(0.0) | 0(0.0) | 5(14.3) | 42(35.3) | ||
| Zifivax | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 7(5.9) | ||
| AstraZeneca | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 6(5.0) | ||
| CanSinoBIO | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 2(1.7) | ||
| Biokangtai | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 1(0.8) | ||
| Mixing vaccination | 0(0.0) | 0(0.0) | 0(0.0) | 2(5.7) | 22(18.5) | ||
| Missing data | 2(0.8) | 0(0.0) | 1(5.5) | 1(2.8) | 2(1.7) | ||
| Disease severity | 47.49 | <0.001 | |||||
| Asymptomatic | 17(6.9) | 0 | 2(11.1) | 7(20.0) | 82(68.9) | ||
| Mild/Ordinary | 176(71.3)a | 12(92.3) | 15(83.3) | 27(77.1) | 37(31.1) | ||
| Moderate/Severe | 54(21.9) | 1(7.7) | 1(5.6) | 1(2.9) | 0(0.0) | ||
| Underlying diseases | 75(30.4)a | 6(46.2)b | 14(77.8) | 27(77.1) | 101(84.9) | 111.59 | <0.001 |
| Fever | 167(67.6)a | 2(15.4) | 2(11.1) | 35(100.0) | 33(27.7) | 77.77 | <0.001 |
| Fatigue | 28(33.6)a | 10(76.9)b | 7(38.9) | 11(31.4) | 24(20.2) | 29.32 | <0.001 |
| Cough | 143(57.9)a | 3(23.1) | 2(11.1)c | 14(40.0) | 51(42.9) | 24.57 | <0.001 |
| Nasal obstruction/Runny nose | 8(3.2)a | 3(23.1) | 1(5.6) | 7(20.0) | 22(18.5) | 30.41 | <0.001 |
| Chills | 2(0.8) | 1(7.7) | 1(5.6) | 3(8.6) | 5(4.2) | 12.05 | 0.008 |
| Shortness of breath | 30(12.2)a | 1(7.7) | 2(11.1)c | 3(8.6)d | 0(0.0) | 21.85 | <0.001 |
| Abdominal pain | 0(0.0) | 0(0.0) | 0(0.0) | 3(8.6) | 2(1.7) | 13.08 | 0.005 |
| Palpitations | 0(0.0) | 0(0.0) | 0(0.0) | 2(5.7) | 1(0.8) | 9.803 | 0.026 |
| Chest pain | 0(0.0)a | 0(0.0) | 0(0.0) | 5(14.3) | 23(19.3) | 55.44 | <0.001 |
| Dry/sore/itchy throat | 29(11.7)a | 2(15.4) | 1(5.6) | 10(28.6) | 39(32.8) | 26.26 | <0.001 |
| Muscle soreness | 24(9.7) | 1(7.7) | 0(0.0) | 4(11.4) | 3(2.5) | 8.571 | 0.049 |
| Stomach distention | 0(0.0) | 1(7.7) | 1(5.6) | 0(0.0) | 0(0.0) | 12.91 | 0.005 |
| Impaired taste | 0(0.0)a | 0(0.0) | 1(5.6) | 2(5.7) | 5(4.2) | 14.60 | 0.003 |
| Diarrhea | 20(8.1) | 0(0.0) | 1(5.6) | 3(8.6) | 3(2.5) | 5.169 | 0.211 |
| Headache | 18(7.3) | 1(7.7) | 0(0.0) | 6(17.1) | 12(10.1) | 5.249 | 0.218 |
| Dizziness | 11(4.5) | 1(7.7) | 0(0.0) | 4(11.4) | 9(7.6) | 4.640 | 0.254 |
| Chest tightness | 0(0.0) | 0(0.0) | 1(5.6) | 0(0.0) | 2(1.7) | 8.644 | 0.056 |
| Nausea/vomiting | 9(3.6) | 1(7.7) | 0(0.0) | 3(8.6) | 6(5.0) | 3.303 | 0.412 |
| Impaired smell | 0(0.0) | 0(0.0) | 0(0.0) | 1(2.9) | 0(0.0) | 8.727 | 0.153 |
All data are presented as n (%) besides age; a: Wild-type and Omicron variant had statistical difference; b: Alpha variant was significantly different from Omicron variant; c: Beta variant was significantly different from Omicron variant; d: Delta variant and Omicron variant had statistical difference.