Pathway Analysis of Circular RNAs, miRNAs, and mRNAs.
(A) The circus plot shows cross-dataset pathway results of differentially expressed mRNAs, circRNAs, and miRNAs, indicating metabolic pathways' significant role in breast cancer. (B) Gene ontology analysis of extracted mRNAs, parental genes of circRNAs, and target genes of miRNAs from the ceRNA network. Enrichment in cancer-related biological processes such as “extracellular matrix organization” and “growth factor activity”. (C) Kyoto Encyclopedia of Genes and Genomes pathway analysis of extracted mRNAs, parental genes of circRNAs, and target genes of miRNAs from the ceRNA network. Enrichment in cancer-related pathways such as “p53 signaling pathway” and “ECM-receptor interaction."