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. 1998 Jul;180(13):3491–3494. doi: 10.1128/jb.180.13.3491-3494.1998

FIG. 3.

FIG. 3

Phylograms of the family of proteins or protein domains to which KtrA (A) and KtrB (B) belong. Alignment of protein sequences was first done with the program CLUSTAL W and was then improved by hand before a phylogram was calculated (32). Phylograms were drawn with the program TREEVIEW (19). For the different entries, the gene or protein and the GenBank accession number are given within parentheses. (A) KtrA Ssp, KtrA Val, KtrA2 Bsu, KtrA1 Bsu, KtrA Aae, KtrA Mge, KtrA Mpn, and KtrA Bbu, complete KtrA sequences from Synechocystis strain PCC6803 (sll049 in D64006), V. alginolyticus (D89592, this work), B. subtilis (YkqB in Z99111), B. subtilis (YuaA in Z99119), A. aeolicus (Aq1503 in AE000743), M. genitalium (MG323 in U39714), M. pneumoniae (H08-orf 231 in AE001046), and B. burgdorferi (BB075 in AE001172), respectively; KtrA Tet, an incomplete N-terminal KtrA sequence of 198 residues from T. ethanolicus (AF001974); TrkAN Eco, TrkAN Val, TrkA Mja, and TrkAC Eco and TrkAC Val, the N-terminal TrkA half from E. coli (X52114, residues 1 to 232) (23) and V. alginolyticus (D86411, residues 1 to 232), the complete TrkA sequence from Methanococcus jannaschii (MJ1105), and the C-terminal TrkA half from E. coli (X52114, residues 233 to 458) (23) and V. alginolyticus (D86411, residues 233 to 458), respectively; KchX Ssp and KefC Eco, C-terminal putative NAD+-binding domain from putative K+ channel from Synechocystis strain PC6803 (sllo993, residues 127 to 3365) and from KefC of K+-efflux channel from E. coli (P03819 in X56742, residues 399 to 620) (12), respectively. (B) KtrB Bbu, KtrB Ssp, KtrB Aae, KtrB Ehi, KtrB Val, KtrB1 Bsu, KtrB2 Bsu, KtrB Mge, and KtrB Mpn, KtrB from B. burgdorferi (BB0724 in AE001172), Synechocystis strain PCC6803 (sll1509 in D90911), A. aeolicus (Aq1504 in AE000743), E. hirae (NtpJ, D17462) (31), V. alginolyticus (D89592, this work), B. subtilis (YubG in Z99119), B. subtilis (YkrM in Z99111), M. genitalium (MG322 in U39714), and M. pneumoniae (H08-orf 565 in AE000036), respectively; KtrB Tet, a 350-residue C-terminal KtrB fragment from T. ethanolicus (AF001974); Trk1 Sce and Trk2 Sce, Trk membrane domains from Saccharomyces cerevisiae (P12685, residues 1 to 138 and 755 to 1235 [8], and P28584, residues 1 to 141 and 442 to 889 [11], respectively); TrkH Val and TrkH Mja, TrkH from V. alginolyticus (D86411) (17) and M. jannaschii (MJ1485), respectively.