Table 2.
Diagnostic performance of the hemoglobin/mean corpuscular volume index in differentiating between iron deficiency anemia and thalassemia trait against gold standard diagnostic methods1
|
Diagnostic parameters
|
TT, % (95%CI)
|
IDA, % (95%CI)
|
| Sensitivity | 93.5 (77.2-98.9) | 78.4 (66.2-87.3) |
| Specificity | 78.4 (66.2-87.3) | 93.5 (77.2-98.9) |
| Accuracy | 83.3 (74.5-89.6) | |
| Youden's index | 0.72 | |
| AUC | 0.97 (0.93-1.00) | |
| Kappa coefficient | 0.65 (0.51-0.80) | |
1
α-TT was confirmed by the presence of mutations. β-TT carriers were confirmed by hemoglobin electrophoresis at pH 8.6 and HbA2 levels > 3.5%. And ferritin measurement was confirmed for iron deficiency anemia.
IDA: Iron deficiency anemia; TT: Thalassemia trait; 95%CI: 95% confidence interval; AUC: Area under the receiver operating characteristic curve.