TABLE II -.

Suggested regimens for antimicrobial therapy in uncomplicated cystitis. Recommendations of the European Association of Urology (EAU) (8)

Antimicrobial	Daily dose	Duration of therapy	Comments
b.i.d. = twice daily; SD = single dose; t.i.d. = three times daily.
Reproduced from Bonkat G, Bartoletti R, Bruyere F, et al. EAU Guidelines on Urological Infections. Edn. presented at the EAU Annual Congress, Milan, Italy, 2023. ISBN 978-94-92671-19-6 and published by uroweb.org as an Open Access article under the CC BY 4.0 license.
First-line women
Fosfomycin trometamol	3 g SD	1 day	Recommended only in women with uncomplicated cystitis.
Nitrofurantoin macrocrystal	50-100 mg four times a day	5 days
Nitrofurantoin monohydrate/macrocrystals	100 mg b.i.d.	5 days
Nitrofurantoin macrocrystal prolonged release	100 mg b.i.d.	5 days
Pivmecillinam	400 mg t.i.d.	3-5 days
Alternatives
Cephalosporins (e.g., cefadroxil)	500 mg b.i.d.	3 days	Or comparable
If the local resistance pattern for Escherichia coli is <20%
Trimethoprim	200 mg b.i.d.	5 days	Not in the first trimester of pregnancy
Trimethoprim-sulfamethoxazole	160/800 mg b.i.d.	3 days	Not in the last trimester of pregnancy
Treatment in men
Trimethoprim-sulfamethoxazole	160/800 mg b.i.d.	7 days	Restricted to men. Fluoroquinolones can also be prescribed in accordance with local susceptibility testing.