Table 3.

Multivariable analysis of the full cohort (N = 302).

Univariable						Multivariable
Variable	Categories	Hazard ratio	95% CI	P-value	Overall P-value	Hazard ratio	95% CI	P-value	Overall P-value
ECOG	0	Reference	–	–		Reference	–	–
	1-2	1.43	1.08-1.89	0.011		1.40	1.06-1.87	0.019
	3-4	2.06	1.33-3.18	0.001	0.002	1.44	0.90-2.30	0.128	0.049
Treatment	Cisplatin (I)	Reference	–	–		n/a
	Cisplatin (C)	0.78	0.49-1.24	0.3
	Carboplatin (I)	2.07	0.91-4.71	0.082
	Carboplatin (C)	0.95	0.57-1.57	0.838	0.081
Sex	Female	Reference	–	–		n/a
	Male	1.07	0.84-1.36	0.608	0.608
Thoracic RT (yes/no)	No	Reference	–	–		n/a
	Yes	0.83	0.62-1.12	0.23	0.229
Thoracic RT (original)	None	Reference				Reference	–	–
	Concurrent	0.70	0.50-0.97	0.035		0.86	0.60-1.23	0.397
	Sequential	0.85	0.60-1.20	0.351		0.82	0.57-1.19	0.294
	Palliative	1.29	0.87-1.90	0.205	0.005	1.08	0.71-1.64	0.723	0.464
PCI	No	Reference	–	–		Reference	–	–
	Yes	0.44	0.34-0.56	<0.001	<0.001	0.49	0.38-0.65	<0.001	<0.001
T Stage	T0	Reference	–	–		Reference	–	–
	T1	1.51	0.65-3.54	0.338		1.38	0.58-3.31	0.464
	T2	1.78	0.78-4.08	0.171		1.75	0.75-4.09	0.196
	T3	1.78	0.74-4.26	0.197		1.97	0.80-4.82	0.139
	T4	2.43	1.06-5.57	0.036	0.024	2.47	1.07-5.71	0.034	0.011
N Stage	N0	Reference	–	–		n/a
	N1	1.09	0.71-1.66	0.707
	N2	1.43	1.04-1.96	0.027
	N3	1.50	0.91-2.46	0.11	0.085
Age	Continuous	1.02	1.01-1.04	0.001	<0.001	1.01	1.00-1.03	0.083	0.079
LDH	Continuous	1.00	1.00-1.00	0.282	0.282	n/a
Sodium	Continuous	0.98	0.95-1.00	0.084	0.084	n/a
Hemoglobin	Continuous	0.99	0.99-1.00	0.212	0.212	n/a
Smoking (pack years)	Continuous	1.01	1.00-1.01	0.115	0.115	n/a

CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group Performance Status; LDH, lactate dehydrogenase; HR, hazard ratio; PCI, prophylactic cranial irradiation; T-stage, tumor size; N-stage, nodal status.

P-values <0.05 are bolded.

n/a = not applicable.