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. 2023 Dec 6;13:1233039. doi: 10.3389/fonc.2023.1233039

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Copyright © 2023 Schultz, Zimmerman, Moelans, Chrusciel, Krijgh, van Diest, Huhtaniemi and Coelingh Bennink

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ZP3 protein is expressed in human cancer tissues and is cytoplasmic. Immunohistochemical detection of ZP3 protein in (A, B) lung squamous cell carcinoma; (C, D) ovarian adenocarcinoma; (E), (F) breast carcinoma and (G, H) esophageal adenocarcinoma. Scale bar = 50 µm. (I) The ZP3 antibody specifically detects ZP3 in the zona pellucida of oocytes in ovarian follicles (indicated by black arrow), while no staining of oocytes in ovarian follicles is observed in the absence of the antibody (J; indicated by red arrow). Scale bar = 100 µm (I, J).