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. 2023 Oct 12;8(6):1547–1556. doi: 10.1002/lio2.1166

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© 2023 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Matrix metalloproteinase‐1 (MMP‐1) levels in saliva from 792 clinical specimens. (A) Salivary levels of MMP‐1 in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) patients were determined using an enzyme‐linked immunosorbent assay kit. The OSCC patients had significantly higher saliva MMP‐1 levels than the OPMD patients. (B) Receiver operating characteristic (ROC) curve showing the diagnostic efficacy of salivary MMP‐1 for discriminating OSCC and OPMD patients. The area under the ROC curve (AUC) was 0.8869, p < .0001.