TABLE 3.
Baseline clinicopathological characteristics according to the salivary MMP‐1.
| Variable | Salivary MMP‐1 (pg/mL) | p‐value | |
|---|---|---|---|
| <2060 (n = 305) | ≥2060 (n = 174) | ||
| Age (years) | |||
| <65 | 257 (84.3%) | 136 (78.2%) | .094 |
| ≥65 | 48 (15.7%) | 38 (21.8%) | |
| Gender | |||
| Male | 278 (91.2%) | 161 (92.5%) | .599 |
| Female | 27 (8.8%) | 13 (7.5%) | |
| Alcohol consumption | |||
| No | 104 (34.1%) | 56 (32.2%) | .669 |
| Yes | 201 (65.9%) | 118 (67.8%) | |
| Betal nut chewing | |||
| No | 60 (19.7%) | 25 (14.4%) | .143 |
| Yes | 245 (80.3%) | 149 (85.6%) | |
| Cigarettes smoking | |||
| (−) | 49 (16.1%) | 27 (15.5%) | .874 |
| (+) | 256 (83.9%) | 147 (84.5%) | |
| pT classification | |||
| T1–T2 | 222 (72.8%) | 54 (31.0%) | <.001 a |
| T3–T4 | 83 (27.2%) | 120 (69.0%) | |
| pN classification | |||
| N0 | 224 (73.4%) | 85 (48.9%) | <.001 a |
| N1–N3 | 81 (26.6%) | 89 (51.1%) | |
| Overall stage | |||
| I–II | 172 (56.4%) | 37 (21.3%) | <.001 a |
| III–IV | 133 (43.6%) | 137 (78.7%) | |
| ENE | |||
| Absent | 258 (84.6%) | 119 (68.4%) | <.001 a |
| Present | 47 (15.4%) | 55 (31.6%) | |
| Cell differentiation | |||
| W‐D/M‐D | 282 (92.5%) | 150 (86.2%) | .027 a |
| P‐D | 23 (7.5%) | 24 (13.8%) | |
| LVI | |||
| Absent | 282 (92.5%) | 148 (85.1%) | .010 a |
| Present | 23 (7.5%) | 26 (14.9%) | |
| PNI | |||
| Absent | 230 (75.4%) | 92 (53.2%) | <.001 a |
| Present | 75 (24.6%) | 81 (46.8%) | |
| DOI | |||
| <5 mm | 101 (33.1%) | 16 (9.2%) | <.001 a |
| ≥5 mm | 204 (66.9%) | 158 (90.8%) | |
Abbreviations: DOI, depth of invasion; ENE, extranodal extension; LVS, lymphovascular invasion; M‐D, moderately differentiated; P‐D: poorly differentiated; PNI, perineural invasion; W‐D, well‐differentiated.
a
Statistically significant.