Table 4.
OCT Measurements by Diagnostic Group, Dementia Etiology, and CDR Stage
| Control | MCI | Dementia | p | CDR 0 | CDR 0.5 | CDR 1 | p | |
|---|---|---|---|---|---|---|---|---|
| Central Subfield Thickness (μm) | 272.0 (30.0) | 262.0 (27.5) | 252.1 (37.7) | 0.040 | 272.3 (29.9) | 258.5 (28.2) | 257.2 (44.3) | 0.133 |
| Macula Volume (mm3) | 10.0 (0.7) | 9.6 (0.9) | 9.3 (1.2) | 0.011 | 9.9 (0.7) | 9.5 (0.9) | 9.3 (1.2) | 0.030c |
| Average Macula Thickness (μm) | 278.8 (18.4) | 269.2 (17.8) | 259.3 (30.4) | 0.003 a | 278.7 (18.4) | 266.4 (21.5) | 261.3 (31.7) | 0.021c |
| GCL + IPL Thickness (μm) | 78.6 (5.3) | 73.3 (10.0) | 64.2 (13.4) | < 0.001 a | 78.6 (5.3) | 71.3 (11.4) | 64.1 (13.6) | < 0.001 d |
| Minimal GCL + IPL Thickness (μm) | 74.5 (7.4) | 66.1 (14.7) | 55.1 (18.3) | < 0.001 b | 74.5 (7.4) | 63.9 (15.7) | 54.7 (19.7) | < 0.001 d |
| RNFL Thickness (μm) | 87.9 (9.7) | 82.3 (12.6) | 78.9 (16.2) | 0.032 | 87.9 (9.7) | 80.8 (14.6) | 81.6 (12.5) | 0.066 |
| Control | MCI | AD | DLB | FTD | VCID | p | ||
| Central Subfield Thickness (μm) | 272.0 (30.0) | 262.0 (27.5) | 249.3 (29.8) | 267.0 (36.1) | 250.8 (22.0) | 225.8 (57.3) | 0.015 | |
| Macula Volume (mm3) | 10.0 (0.7) | 9.6 (0.9) | 9.6 (0.6) | 9.1 (1.3) | 9.6 (0.4) | 8.6 (1.8) | 0.007 e | |
| Average Macula Thickness (μm) | 278.8 (18.4) | 269.2 (17.8) | 267.6 (17.4) | 257.3 (34.1) | 265.4 (11.6) | 238.0 (48.6) | 0.002 f | |
| GCL + IPL Thickness (μm) | 78.6 (5.3) | 73.3 (10.0) | 67.5 (10.3) | 60.1 (14.4) | 71.6 (8.1) | 60.7 (18.9) | < 0.001 g | |
| Minimal GCL + IPL Thickness (μm) | 74.5 (7.4) | 66.1 (14.7) | 55.8 (17.6) | 52.7 (20.7) | 70.9 (5.9) | 48.2 (17.0) | < 0.001 g | |
| RNFL Thickness (μm) | 87.9 (9.7) | 82.3 (12.6) | 83.3 (20.1) | 75.6 (13.1) | 75.5 (14.5) | 77.8 (14.0) | 0.087 |
Mean (SD). Bold signifies significance after correction for multiple comparisons (corrected p < 0.0083). MCI, mild cognitive impairment; GCL, ganglion cell layer; IPL, internal plexiform layer; RNFL, retinal nerve fiber layer. aPost-hoc comparisons: Controls and MCI are different from Dementia, but not each other. bPost-hoc comparisons: Controls are different from MCI and Dementia; MCI is different from Dementia. cPost-hoc comparisons: CDR 0 different from CDR 0.5 and 1; CDR 0.5 not different from CDR 1. dPost-hoc comparisons: All CDR groups different from each other.ePost-hoc comparisons: Controls are different from VCID and DLB. fPost-hoc comparisons: Controls are different from VCID, and DLB; MCI is different from VCID. gPost-hoc comparisons: Controls are different from MCI, AD, VCID, and DLB; MCI is different from AD, DLB, and VCID.