Table 5.
Strength of Association Between OCT Measures and Cognitive Tests, Global Ratings, and MRI
| Central Subfield |
Macula Volume |
Macula Thickness |
GCL + IPL Thickness |
Minimum GCL + IPL |
RNFL Thickness |
|
|---|---|---|---|---|---|---|
| Cognitive Tests and Ratings | ||||||
| MoCA | 0.122 (0.165) | 0.143 (0.106) | 0.218 (0.013) | 0.357 (< 0.001) | 0.363 (< 0.001) | −0.053 (0.556) |
| HVLT – Immediate Recall | 0.104 (0.236) | 0.077 (0.384) | 0.192 (0.029) | 0.292 (< 0.001) | 0.301 (< 0.001) | 0.053 (0.553) |
| HVLT – Delayed Recall | 0.077 (0.380) | 0.112 (0.207) | 0.215 (0.014) | 0.250 (0.004) | 0.316 (< 0.001) | 0.099 (0.270) |
| Trail making A | 0.022 (0.807) | 0.034 (0.702) | 0.030 (0.735) | −0.143 (0.099) | −0.150 (0.089) | −0.047 (0.600) |
| Trail making B | −0.032 (0.723) | 0.001 (0.993) | 0.018 (0.839) | −0.133 (0.134) | −0.168 (0.061) | −0.069 (0.453) |
| Verbal Fluency (Animals) | 0.160 (0.067) | 0.037 (0.674) | 0.035 (0.694) | 0.239 (0.005) | 0.316 (< 0.001) | 0.176 (0.048) |
| MINT | 0.026 (0.772) | −0.058 (0.508) | −0.040 (0.647) | −0.102 (0.236) | −0.117 (0.183) | −0.036 (0.687) |
| Numbers – Forwards | 0.105 (0.234) | 0.075 (0.396) | 0.058 (0.514) | 0.211 (0.014) | 0.152 (0.083) | 0.096 (0.287) |
| Numbers – Backwards | 0.117 (0.186) | −0.010 (0.911) | −0.019 (0.833) | 0.175 (0.043) | 0.131 (0.136) | −0.025 (0.784) |
| Number-Symbol Coding Task | 0.108 (0.228) | 0.018 (0.872) | 0.026 (0.776) | 0.167 (0.057) | 0.218 (0.014) | 0.128 (0.161) |
| Composite z-score | 0.140 (0.127) | 0.103 (0.267) | 0.144 (0.119) | 0.295 (0.001) | 0.368 (< 0.001) | 0.208 (0.025) |
| CDR-SB | −0.095 (0.278) | −0.137 (0.118) | −0.177 (0.043) | −0.376 (< 0.001) | −0.339 (< 0.001) | −0.053 (0.556) |
| MRI (all groups) | ||||||
| Hippocampal Volume (mm3) | 0.260 (0.100) | 0.478 (0.002) | 0.460 (0.003) | 0.589 (< 0.001) | 0.514 (< 0.001) | 0.554 (< 0.001) |
| Hippocampal Occupancy Scores | 0.108 (0.497) | 0.048 (0.770) | 0.094 (0.566) | 0.443 (0.003) | 0.372 (0.015) | 0.288 (0.071) |
| MRI (Controls, MCI due to AD, AD only) | ||||||
| Hippocampal Volume (mm3) | 0.383 (0.044) | 0.477 (0.012) | 0.445 (0.020) | 0.644 (< 0.001) | 0.531 (0.004) | 0.621 (< 0.001) |
| Hippocampal Occupancy Scores | 0.232 (0.235) | 0.002 (0.991) | 0.037 (0.856) | 0.510 (0.005) | 0.373 (0.051) | 0.315 (0.103) |
Partial correlation, controlling for age (p-value) for cognitive measures; Bivariate correlation (p-value) for MRI measures. Bold signifies significance after correction for multiple comparisons (adjusted p = 0.0042 for cognitive measures and adjusted p = 0.0125 for MRI measures). GCL, ganglion cell layer; IPL, internal plexiform layer; RNFL, retinal nerve fiber layer; MoCA, Montreal Cognitive Assessment; HVLT, Hopkins Verbal Learning Task; MINT, Multilingual Naming Test; CDR-SB, Clinical Dementia Rating Sum of Boxes.