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. 2023 Oct 4;62(50):20769–20776. doi: 10.1021/acs.inorgchem.3c02459

Table 1. Radiolabeling Parameters for Chelators Discussed with 68Ga.

  radiolabeling conditions
 
chelator [L]/M pH T/°C t/min RCC/% stability to serum/%
Dpaa 10–4 7.4 37 15 9522 0,a,22, 58b,24
DOTA 10–5 4–5 80 5 95.228 80.0b,24
NOTA 10–6 4–5 25 5 98.628 98.0b,24
dedpa 10–7 4.5 25 10 >9925 77.8b,26
CHXdedpa 10–5 4.0 25 10 >9926 90.5b,26
CHXoctapa 10–5 4.0 25 10 >9926 74.7b,26
a

Conditions: 90% serum, 30 min, 37 °C.

b

Conditions: 50% serum, 2 h, 37 °C.