Table 1. Radiolabeling Parameters for Chelators Discussed with 68Ga.
| radiolabeling
conditions |
||||||
|---|---|---|---|---|---|---|
| chelator | [L]/M | pH | T/°C | t/min | RCC/% | stability to serum/% |
| Dpaa | 10–4 | 7.4 | 37 | 15 | 9522 | 0,a,22, 58b,24 |
| DOTA | 10–5 | 4–5 | 80 | 5 | 95.228 | 80.0b,24 |
| NOTA | 10–6 | 4–5 | 25 | 5 | 98.628 | 98.0b,24 |
| dedpa | 10–7 | 4.5 | 25 | 10 | >9925 | 77.8b,26 |
| CHXdedpa | 10–5 | 4.0 | 25 | 10 | >9926 | 90.5b,26 |
| CHXoctapa | 10–5 | 4.0 | 25 | 10 | >9926 | 74.7b,26 |
Conditions: 90% serum, 30 min, 37 °C.
Conditions: 50% serum, 2 h, 37 °C.