TABLE 3.
Screening of the solvent in the reaction of hydroamination promoted by 2b.
| Entry a | Solvent | Yield (%) b |
|---|---|---|
| 1 | CH3CN | 70 |
| 2 | 1,4-Dioxane | 20 |
| 3 | Dimethylsulfoxide | 13 |
| 4 | C2H2Cl4 | 45 |
| 5 | Toluene | 50 |
| 6 | Ethylene Carbonate | 35 |
Reaction conditions: 1.0 mmol aniline, 1.5 mmol phenylacetylene, 1% mol 2b, 2% mol Ag salt, 90°C oil-bath, 16h, solvent (1 mL).
Yields are averaged from two runs and determined by 1H-NMR, analysis through internal standard.