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. 2023 Dec 20;42:346. doi: 10.1186/s13046-023-02911-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Proposed mechanisms of RRM2 inhibition by COH29 in ATRT cells via DNA damage induction and apoptosis activation. A The correlation of mRNA gene expression between RRM2 and BRCA1 in eleven ATRT cell lines. Data were analyzed from the project Expression Public 23Q2 dataset (DepMap). B Pearson correlation test between the RNA expression level of BRCA1 and RRM2 in human TMU-Taipei VGH cohort (n = 28) and PedcBioPortal_PBTA_cohort (n = 67). RNA expression was normalized using logarithm base 2. C The correlation of BRCA1 mRNA level with patient’s overall survival (OS) in TMU-Taipei VGH cohort (n = 26), and PBTA cohort from PedcBioPortal (n = 48). D Proposed schematic of COH29 treatment induces DNA damage and activates apoptosis in ATRT