TABLE 4.

Obesogens affect multiple tissues and endpoints in animal studies

Increased inflammation	Dysfunctional adipocytes	NAFLD	Altered microbiome	Altered satiety and appetite neurons	Stimulate food intake	Stimulate weight gain with no change in food intake	Larger effect on weight gain with a high-fat diet	Insulin resistance	Leptin resistance	Transgenerational epigenetic inheritance
TBT	TBT	TBT	BPA, BPS	TBT	BPA	TBT	TBT	Tolyfluanid	Chlorpyrifos	TBT
BPA	BPA	BPA	DEHP	BPA	DEHP	Chlorpyrifos	BPA	BPA	BPA	BPA
DEHP	DEHP	DEHP	TCDD		OPFRs	DES	BBzP	PM2.5	PM2.5	DEHP, DBP
PBDEs	TPhP	DDT	PBDEs				DDT	PFOS	PFOA	DDT
Triclosan		PCBs	PCBs				Permethrin	Atrazine	OPFRs	Jet fuel mixture
PM2.5 (air pollution)		BaP	PAHs (air pollution)				Atrazine	Cadmium	Cadmium
CMC		Triclosan	Triclosan				Chlorpyrifos	Permethrin
Diazinon		PFAS	Methyl Paraben					Chlorpyrifos
PCBs								OPFRs

In addition to increasing the number and size of adipocytes, obesogens also affect other tissues and mechanisms in animal studies. Several main effects of obesogens are shown here to indicate the diversity of the effects. Although the chemicals shown here are reported to show that effect, this does not mean that other obesogens may not also show similar effects. In many cases, specific obesogens have not been examined for effects on tissues and mechanisms shown. Data for this table comes from [3].

BaP, benzo[a]pyrene; BBzP, butyl benzyl phthalate; BPA, bisphenol A; BPS, bisphenol S; CMC, carboxymethylcellulose; DBP, dibutyl phthalate; DDT, dichlorodiphenyltrichloroethane; DEHP, diethyl hexyl phthalate; DES, diethylstilbestrol; NAFLD, nonalcoholic fatty liver disease; OPFRs, organophosphate flame retardants; PAHs, poly aromatic hydrocarbons; PBDEs, polybrominated diethyl ethers; PCBs, polychlorinated biphenyls; PFAS, per- and poly-fluoroalkyl substances; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonate; PM_2.5, particulate matter; TBT, tributyltin; TCDD, 2,3,7,8 -tetrachlorodibenzo-p-dioxin; TPhP, triphenyl phosphate.