Table 1.
Subgroup analysis of the correlation between the expression levels of glycolysis markers and OS according to the specific glycolysis markers, region, sample, and detection method
| Subgroup | HR (95% CI) | Heterogeneity I2 (%), P |
|---|---|---|
| Indicators: | ||
| MLXIPL | 1.88 (1.02, 3.47) | NA |
| GLUT4 | 1.44 (0.40, 5.20) | NA |
| PKM2 | 1.93 (1.70, 2.18) | I2 = 0.0%, P = 0.704 |
| MAP17 | 1.64 (1.36, 1.98) | NA |
| PFKFB3 | 2.45 (1.09, 5.52) | NA |
| STMN1 | 2.57 (1.43, 4.65) | I2 = 49.6%, P = 0.138 |
| PGM1 | 1.71 (1.11, 2.63) | NA |
| MCT4 | 1.64 (1.30, 2.07) | I2 = 0.0%, P = 0.755 |
| GLUT1 | 1.47 (1.05, 2.05) | I2 = 44.1%, P = 0.181 |
| CDK1 | 1.99 (0.37, 10.70) | NA |
| HK-2 | 2.12 (1.66, 2.71) | I2 = 0.0%, P = 0.604 |
| CA9 | 2.26 (1.47, 3.47) | I2 = 41.1%, P = 0.165 |
| Homer1 | 1.66 (0.78, 3.54) | NA |
| ASCT2 | 1.76 (1.12, 2.76) | NA |
| LDHB | 0.66 (0.46, 0.93) | NA |
| TRIM35 | 0.60 (0.39, 0.92) | NA |
| PGK-1 | 3.09 (1.31, 7.29) | NA |
| GLUT2 | 1.65 (0.86, 3.20) | I2 = 0.0%, P = 0.347 |
| Region: | ||
| China | 1.66 (1.43, 1.94) | I2 = 67.4%, P < 0.001 |
| Japan | 2.37 (1.44, 3.88) | I2 = 28.1%, P = 0.234 |
| Germany | 1.95 (1.34, 2.83) | I2 = 0.0%, P = 0.493 |
| Taiwan | 2.70 (1.64, 4.45) | I2 = 21.5%, P = 0.280 |
| South Korea | 2.19 (1.14, 4.20) | NA |
| Hong Kong | 1.75 (1.02, 3.00) | NA |
| US | 1.86 (1.23, 2.82) | NA |
| Sample: | ||
| Tissue | 1.80 (1.57, 2.05) | I2 = 60.3%, P < 0.001 |
| Serum | 1.82 (1.29, 2.56) | I2 = 0.0%, P = 0.704 |
| Detection method: | ||
| IHC | 1.80 (1.56, 2.07) | I2 = 63.4%, P < 0.001 |
| qRT-PCR | 1.80 (1.30, 2.50) | I2 = 0.0%, P = 0.885 |
| IF | 2.45 (1.09, 5.52) | NA |
| ELISA | 1.69 (1.02, 2.81) | NA |
MLXIPL MLX interacting protein like, GLUT4 glucose transporter 4, PKM2 pyruvate kinase M2, MAP17 membrane-associated protein 17, PFKFB3 phosphofructokinase-2/fructose-2,6-bisphosphatase 3, STMN1 stathmin 1, PGM1 phosphoglucomutase 1, MCT4 monocarboxylic acid transporter 4, GLUT1 glucose transporter 1, CDK1 cyclin dependent kinase 1, HK-2 hexokinase 2, CA9 carbonic anhydrase IX, ASCT2, alanine-serine-cysteine transporter 2, LDHB lactate dehydrogenase B, TRIM35, tripartite motif-containing 35, PGK-1 phosphoglycerate kinase-1, GLUT2 glucose transporter 2, HR hazard ratio, IHC immunohistochemistry, qRT-PCR quantitative real time polymerase chain reaction, IF immunofluorescence, ELISA enzyme linked immunosorbent assay