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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Pain. 2023 Jun 15;164(11):2501–2515. doi: 10.1097/j.pain.0000000000002956

Fig. 2: Changes of colonic inflammation and NFEPP effects on visceromotor responses (VMRs) during acute DSS colitis.

Fig. 2:

A. DAI of DSS colitis mice over time (N=15–43, combined data of all cohorts, compared to day 1). B-E. Histology (B, H&E staining), histological damage score (C), MPO activity (D) and tissue pH (E) of the colon from healthy control (HC, N=8–11) and DSS colitis mice (N=5–10) at different time points. Arrows in (B) denote infiltrating inflammatory cells. F. Study design with injection regimen (color coded) and daily VMR measurements (80 μl colorectal distension, day 1 - day 5) after NFEPP administration (0.4 mg/kg s.c.) in DSS colitis mice (N=5). Abbreviations: BID, bis in die (twice daily). DAI, disease activity index. DSS, dextran sulphate sodium. H&E, haematoxylin and eosin. MPO, myeloperoxidase. * p<0.05. ** p<0.01. *** p<0.001. A, C, D: Kruskal-Wallis test, Dunńs test. E: Welch ANOVA, Dunnett T3 test. F: Friedman test, Dunńs test.