Table 2.
Praziquantel cure rate and egg reduction rate stratified by sex, age category, infection intensity, and co-infection status among S. mansoni-infected pre-school children
| Variables | Pre-treatment egg count per gram of stool | Cure status | Egg reduction rate (ERR) | WHO reference threshold for ERR [30] | |||
|---|---|---|---|---|---|---|---|
| Median (IQR) | Cured, n (%) | Not Cured, n (%) | P | ||||
| Overall | 72 (24–228) | 201 (85.2%) | 35 (14.8%) | 93.3% | ≥ 90 | ||
| Sex | Female | 84 (24–216) | 82 (85.4%) | 14 (14.6%) | 0.92 | 92.0% | |
| Male | 72 (24–231) | 119 (85.0%) | 21 (15.0%) | 94.5% | |||
| Age category | < 6 years | 72 (24–168) | 61 (85.9%) | 10 (14.1%) | 0.83 | 92.5% | |
| ≥ 6 years | 72 (24–240) | 140 (84.9%) | 25 (15.2%) | 93.7% | |||
| Infection intensity at baseline | Light | 24 (12–60) | 136 (100%) | – | < 0.001 | 100.0% | |
| Moderate | 186 (132–288) | 55 (83.3%) | 11 (16.7%) | 93.2% | |||
| Heavy | 816 (627–1242) | 10 (29.4%) | 24 (70.6%) | 92.0% | |||
| STH co-infection | No | 60 (24–192) | 143 (86.1%) | 23 (13.9%) | 0.42 | 92.2% | |
| Yes | 96 (48–288) | 58 (82.9%) | 12 (17.1%) | 95.8% | |||
IQR = Interquartile range; SD = Standard deviations; STH = soil-transmitted helminths