TABLE 4.
Antifungal susceptibility of Fusarium species to different antifungal agents
| Drug | Reference | Method | No. isolates | MIC range (µg/mL) | MIC50 (µg/mL)a | MIC90 (µg/mL) | Mode (µg/mL) | GM (µg/mL) |
|---|---|---|---|---|---|---|---|---|
| Fusarium solani species complex | ||||||||
| Amphotericin B | (169) | CLSI | 608 | ≤0.25 to 16 | - | - | 2 | - |
| Itraconazole | (169) | CLSI | 608 | 0.5 to ≥16 | - | - | 16 | - |
| Posaconazole | (169) | CLSI | 608 | 1 to ≥16 | - | - | 8 | - |
| Voriconazole | (169) | CLSI | 608 | 0.5 to ≥16 | - | - | 8 | - |
| Isavuconazole | (175) | EUCAST | 22 | 4 to ≥16 | >16 | >16 | - | 14.02 |
| Olorofim | (173) | CLSI | 16 | 1 to >4 | >4 | >4 | >4 | >4 |
| Manogepix | (174) | CLSI | 19 | ≤0.015* | - | - | - | ≤0.015** |
| Fusarium oxysporum species complex | ||||||||
| Amphotericin B | (169) | CLSI | 226 | ≤0.25 to 16 | - | - | 2 | - |
| Itraconazole | (169) | CLSI | 226 | 1 to ≥16 | - | - | 16 | - |
| Posaconazole | (169) | CLSI | 226 | 0.5–16 | - | - | 2 | - |
| Voriconazole | (169) | CLSI | 226 | 0.5 to ≥16 | - | - | 4 | - |
| Isavuconazole | (175) | EUCAST | 17 | 2 to ≥16 | 8 | >16 | - | 9.41 |
| Olorofim | (173) | CLSI | 45 | 0.06 to >4 | 0.5 | 4 | 0.25 | 0.515 |
| Manogepix | (174) | CLSI | 49 | ≤0.015 to 0.03* | - | - | - | ≤0.015** |
| Fusarium fujikuroi species complex | ||||||||
| Amphotericin B | (169) | CLSI | 151 | 0.5–16 | - | - | 2 | - |
| Itraconazole | (169) | CLSI | 151 | 1 to ≥16 | - | - | 16 | - |
| Posaconazole | (169) | CLSI | 151 | ≤0.25 to ≥16 | - | - | 0.5 | - |
| Voriconazole | (169) | CLSI | 151 | 0.5 to ≥16 | - | - | 2 | - |
| Isavuconazole | (175) | EUCAST | 31 | 4 to ≥16 | >16 | >16 | - | 13.68 |
a
MIC = minimum inhibitory concentration; GM = geometric mean; *, minimal effective concentration; geometric mean MEC/MIC.