TABLE 3.
Summary of KPC variant cases
| No. | Sex/age, years | Infection | Organism | Wild-type | KPC variant | ST | Therapy before the KPC variant was detected | Therapy | Outcome | Pathogen clearance | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Male/59 | Pneumonia | K. pneumoniae | KPC-3 | KPC-31 | ST2502 | CZA, 10 d | Meropenem 2 g tid 3 h | Cure | No | (45) |
| 2 | Male/68 | Bloodstream infection | K. pneumoniae | KPC-3 | KPC-31 | ST512 | CZA,14 d | Meropenem-vaborbactam 1/1 g q8 | Cure | Yes | (44) |
| 3 | Male/40 | Bloodstream infection, pneumonia | K. pneumoniae | KPC-3 | KPC-31 | ST307 | Meropenem, tigecycline, polymyxin B, CZA | Meropenem + polymyxin B | Failure | No | (51) |
| 4 | Female/50+ | Subphrenic abscess | K. pneumoniae | KPC-3 | KPC-8, KPC-31 | ST258 | CZA, 19 d | Piperacillin/tazobactam, gentamicin | NA | No | (46) |
| 5 | Female/70+ | Pneumonia | K. pneumoniae | KPC-3 | KPC-31 | ST258 | CZA, 15 d | Meropenem + polymyxin B | Cure | Yes | (46) |
| 6 | Female/NA | Bloodstream infection, pneumonia | K. pneumoniae | KPC-3 | KPC-31 | ST1519 | CZA, 14 d | Meropenem (increased dose, extended infusion time) + gentamicin | Failure | No | (50) |
| 7 | Female/60 | Pneumonia, wound infection | K. pneumoniae | KPC-3 | KPC-31 | ST101 | CZA, 14 d | CZA + tigecycline | Failure (death) | No | (48) |
| 8 | Male/47 | Intra-abdominal infection | K.pneumoniae | KPC-3 | KPC-31/KPC-39/KPC-47/KPC-48 | NA | CZA, 12 d | Imipenem, tigecycline, gentamicin | Cure | No | (53) |
| 9 | Male/67 | Bloodstream infection, pneumonia | K. pneumoniae | KPC-3 | KPC-3 (A177E, D179Y) | ST258 | CZA, 15 d | Meropenem 1 g q12, 12 d | Cure | Yes | (52) |
| 10 | Female/40+ | Pneumonia, urinary tract infection | K. pneumoniae | KPC-3 | KPC-32 | ST258 | CZA, 14 d | Meropenem | Failure | No | (46) |
| 11 | Male/24 | Bloodstream infection, pneumonia | K. pneumoniae | KPC-2 | KPC-33 | NA | CZA, 33 d | Polymyxin B + gentamicin + tigecycline, meropenem- vaborbactam 25 d | Cure | Yes | (49) |
| 12 | Male/42 | Pneumonia | K. pneumoniae | KPC-2 | KPC-33 | ST11 | CZA, 16 d | Imipenem + amoxicillin/clavulanate + polymyxin B | Failure | No | (11) |
| 13 | NA | Bloodstream infection | K. pneumoniae | KPC-2 | KPC-44 | ST39 | CZA + tigecycline, 14 d | Colistin + trimethoprim/sulfamethoxazole | Cure | Yes | (47) |
| 14 | Female/40+ | Bloodstream infection | E. coli | KPC-3 | KPC-49 | ST131 | CZA, 10 d | Amikacin 500 mg/24 h i.v. | Cure | Yes | (54) |
| 15 | NA | Bloodstream infection | Citrobacter koseri | NA | KPC-82 | NA | CZA, 28 d | Meropenem-vaborbactam | Cure | Yes | (56) |
| 16 | Male/22 | Pneumonia | K. pneumoniae | KPC-2 | KPC-33 | ST11 | CZA, 41 d | Imipenem + CZA | Cure | Yes | (57) |
| 17 | Female/52 | Pneumonia | K. pneumoniae | KPC-2 | KPC-79, KPC-76 | ST11 | CZA, 9 d | CZA + amikacin, meropenem + tigecycline + fosfomycin | Failure | No | (55) |
| 18 | Male/50 | Pneumonia | K. pneumoniae | KPC-2 | KPC-35, KPC-78, KPC-33 | ST859 | CZA, 9 d | CZA + tigecycline + fosfomycin + meropenem | Failure | No | (55) |