TABLE 4.
Antimicrobial susceptibility profiles and carbapenemase assay results of KPC variant-producing strainsa
| Organism | Variants | MIC (mg/L) | Carbapenemase assay | Reference | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ETP | IPM | MEM | CZA | MEV | IMR | COL | TGC | mCIM | Rapid Carba NP | NG-Test Carba 5 | RESIST-5 O.O.K.N.V | GeneXpert | RAPIDEC Carba NP | |||
| K. pneumoniae | KPC-12 | 256(R) | 16(R) | 64(R) | 4(S) | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | (75) |
| NA | KPC-14 | ND | ND | ND | ND | ND | ND | ND | ND | NEG | NEG | POS | ND | POS | NEG | (71) |
| K. pneumoniae | KPC-14 | ND | ≤1(S) | ≤0.125(S) | 64(R) | ND | ND | ND | ND | NEG | NEG | POS | POS | ND | ND | (12) |
| K. pneumoniae | KPC-23 | ND | 512(R) | 512(R) | 16(R) | 4(S) | ND | 1(S) | 4(I) | ND | ND | ND | ND | ND | ND | (76) |
| E. coli | KPC-28 | ND | ND | ND | ND | ND | ND | ND | ND | NEG | NEG | POS | ND | POS | NEG | (71) |
| K. pneumoniae | KPC-31 | >1(R) | <0.25(S) | 2(I) | >8(R) | 0.125(S) | ND | 0.5(S) | 0.5(S) | ND | ND | ND | ND | ND | ND | (44) |
| K. pneumoniae | KPC-31 | ND | ≤1(S) | 4(R) | >256(R) | ND | ND | ND | ND | NEG | NEG | NEG | NEG | ND | ND | (12) |
| K. pneumoniae | KPC-31 | ND | 0.25(S) | 4(R) | >64(R) | 1(S) | ND | 0.5(S,PB) | 2(S) | ND | ND | ND | ND | ND | ND | (41) |
| K. pneumoniae | KPC-33 | 32(R) | 0.5(S) | 4(R) | >64(R) | 2(S) | ND | ND | ND | NEG | ND | ND | ND | POS | ND | (14) |
| K. pneumoniae | KPC-35 | 16(R) | 1(S) | 4(R) | 64(R) | 2(S) | ND | ND | ND | NEG | ND | POS | ND | POS | ND | (14) |
| K. pneumoniae | KPC-36 | >32(R) | >256(R) | >256(R) | 16(R) | 2(S) | ND | ND | 2(S) | ND | ND | POS | ND | POS | ND | (77) |
| K. pneumoniae | KPC-39 | ND | >16(R) | >16(R) | >16(R) | 16(R) | 8(R) | 0.5(S) | 1(S) | ND | ND | ND | ND | ND | ND | (53) |
| K. pneumoniae | KPC-41 | 4(R) | 4(R) | 1(S) | >128(R) | ND | ND | ND | ND | ND | POS | ND | ND | ND | ND | (68) |
| K. pneumoniae | KPC-47 | ND | >16(R) | >16(R) | >16(R) | 16(R) | 16(R) | 1(S) | 1(S) | ND | ND | ND | ND | ND | ND | (53) |
| K. pneumoniae | KPC-48 | ND | 1(S) | 1(S) | >16(R) | 1(S) | 1(S) | 1(S) | 1(S) | ND | ND | ND | ND | ND | ND | (53) |
| E. coli | KPC-49 | ND | 2(I) | 0.5(S) | 16(R) | ND | ND | ≤2(S) | ≤0.5(S) | ND | ND | ND | ND | ND | ND | (54) |
| K. pneumoniae | KPC-50 | 1(I) | 16(R) | 2(I) | >256(R) | <0.125(S) | 2(S) | ND | ND | ND | POS | ND | ND | ND | ND | (69) |
| K. pneumoniae | KPC-51 | ND | 1(S) | 4(R) | 2048(R) | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | (72) |
| K. pneumoniae | KPC-52 | ND | 2(I) | 2(I) | 256(R) | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | (72) |
| K. pneumoniae | KPC-53 | ND | 2(I) | 4(R) | 64(R) | 2(S) | ND | >8(R) | 1(S) | ND | ND | ND | POS | ND | ND | (73) |
| K. pneumoniae | KPC-55 | ND | 1(S) | 2(I) | 0.125(S) | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | (78) |
| K. pneumoniae | KPC-70 | 18 mm (R) | 28 mm (S) | 21 mm (I) | >256(R) | ND | ND | ND | 22 mm (S) | ND | ND | ND | ND | ND | ND | (79) |
| K. pneumoniae | KPC-71 | 16(R) | 0.5(S) | 2(I) | >64(R) | 0.5(S) | ND | ND | ND | NEG | ND | NEG | ND | POS | ND | (14) |
| K. pneumoniae | KPC-74 | 16(R) | 0.5(S) | 1(S) | 128(R) | ND | ND | ND | 8(R) | ND | ND | NEG | ND | ND | ND | (80) |
| K. pneumoniae | KPC-76 | 32(R) | 2(I) | 4(R) | >64(R) | 2(S) | ND | ND | ND | NEG | ND | NEG | ND | POS | ND | (14) |
| K. pneumoniae | KPC-78 | 32(R) | 0.5(S) | 2(I) | >64(R) | 1(S) | ND | ND | ND | NEG | ND | POS | ND | POS | ND | (14) |
| K. pneumoniae | KPC-79 | 32(R) | 4(R) | 8(R) | 64(R) | 4(S) | ND | ND | ND | NEG | ND | POS | ND | POS | ND | (14) |
| Citrobacter koseri | KPC-82 | ND | 4(R) | 2(I) | 128(R) | 0.125(S) | ND | ND | ND | ND | ND | ND | ND | POS | ND | (56) |
| K. pneumoniae | KPC-94 | >2(R) | ≤0.5(S) | 2(I) | >16(R) | ND | ND | 0.5(S) | 1(S) | ND | ND | ND | ND | POS | ND | (81) |
| K. pneumoniae | KPC-95 | >2(R) | 1(S) | 1(S) | >16(R) | ND | ND | 0.5(S) | 0.5(S) | ND | ND | ND | ND | POS | ND | (81) |
| K. pneumoniae | KPC-112 | ND | 0.5(S) | 1(S) | >128(R) | ND | ND | ND | 2(I) | ND | ND | ND | ND | ND | ND | (82) |
| K. pneumoniae | KPC-115 | 0.5(S) | ≤0.25(S) | ≤0.5(R) | 24(R) | ND | ND | ND | ND | ND | ND | POS | ND | ND | ND | (83) |
| K. pneumoniae | KPC-121 | ≥256(R) | 8(R) | 16(R) | ≥256(R) | 32(R) | 8(R) | 0.125(S) | ND | ND | ND | ND | ND | ND | ND | (84) |
| Citrobacter koseri | KPC-123 | ≤0.5(S) | ≤0.5(S) | ≤0.5(S) | 64(R) | ND | ND | 1(S) | ≤0.25(S) | ND | ND | ND | ND | ND | ND | (85) |
a
MIC, minimum inhibitory concentration; KPN, K. pneumoniae; ECO, E. coli; CKO, Citrobacter koseri; ETP, ertapenem; IPM, imipenem; MEM, meropenem; CZA, ceftazidime-avibactam; MEV, meropenem-vaborbactam; IMR, imipenem-relebactam; COL, colistin; PB, polymyxin B; TGC, tigecycline; mCIM, modified carbapenem inactivation method; POS, positive; NEG, negative; ND, not detected.