TABLE 2.
Correlation between vancomycin pharmacokinetics and pharmacokinetic/pharmacodynamic indices of infections caused by ST5-MRSA vs ST764-MRSA isolates
| Characteristica | Total (n = 90) | ST5c (n = 44) |
ST764 (n = 46) |
P valued |
|---|---|---|---|---|
| PKb | ||||
| Cmin, mg/L | 11.18 (7.53,16.70) | 10.09 (5.03,13.72) | 14.37 (8.36, 19.61) | 0.011 |
| Cmax, mg/L | 26.31 (19.73, 32.34) | 25.78 (20.68, 30.02) | 27.94 (19.63,34.40) | 0.522 |
| AUC0-24, mg·h/L | 421 (327, 570) | 398 (329, 482) | 456 (322, 612) | 0.338 |
| PK/PD | ||||
| AUC0-24/MIC | 625 (415, 912) | 500 (365, 659) | 732 (505,1176) | <0.001 |
a
PK, pharmacokinetic; PK/PD, pharmacokinetic/pharmacodynamic; Cmin, trough concentration; Cmax, peak concentration; AUC0-24, 24-hour area under the curve; AUC0-24/MIC, 24-hour area under the curve over minimal inhibitory concentration.
b
All the PK parameters were calculated as the weighted average values.
c
Continuous variables were expressed as median (interquartile range) in the table.
d
P values< 0.05 are shown in bold.