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The delayed drug resistance effect of SFI in NSCLC cells. (A, B, C, D) According to the MTT method, the cell proliferation inhibition rate and IC50 of gefitinib (1, 3, 9, 27, 81, 243, 729, 2187 nmol/L) and RI of each induced drug-resistant cells were measured after 48 h of treatment in four stages. Data are expressed as mean ± SEM (n = 3) *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 compared to gefitinib alone inducing gefitinib-resistant PC9-GR cells.
