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. 2023 Dec 15;16(1):2292375. doi: 10.1080/20002297.2023.2292375

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — MAT2A-knockdown reduced inflammation in P. gingivalis-infected hGFs.

HGFs were transfected with siRNA for 72 h. (a&b) The efficiency of three siRNA plasmids to knock down MAT2A was detected by Western blot and qPCR, respectively. HGFs with MAT2A or scrambled siRNA were infected with P. gingivalis (MOI = 100). (c) Gene transcription of inflammatory cytokines was assessed by qPCR at 3 h and (d)protein levels were detected by Western blot at 24 h. (e) IL-6, MCP-1, and (f) SAM in the culture supernatants of 24 h were detected by ELISA. Data are presented as the mean ± SD (n = 3). *p < 0.05; **p < 0.01.