Figure 6.

NF-κB/MAPK pathway was involved in the enhanced MAT2A expression.

(a) HGFs were time-dependently infected with P. gingivalis (MOI = 100). The total and phosphorylated protein expression levels of NF-κB and MAPK were analyzed by Western blot. (b) HGFs were pretreated with or without PF9366 for 0.5 h and then treated with P. gingivalis for 0.5 h. The total and phosphorylated protein expression levels of NF-κB and MAPK were analyzed. Data are presented as the mean ± SD (n = 3). *p < 0.05; **p < 0.01 versus control. #p < 0.05; ##p < 0.01.