Table 3.
Summary of studies employing cobalt chloride to induce hypoxia in optical cells.
| Cell type | Species | Dose | Reference |
|---|---|---|---|
| 661W cell line | Mouse | 200 μM | (Kunimi et al., 2019; Lee et al., 2020) |
| 661W cell line | Mouse | 300 μM | (Rodriguez et al., 2021) |
| Endothelial cells | Human | 150 μM | (Jiang et al., 2021) |
| Müller cells | Rabbit | 250 mM | (Lu et al., 2013) |
| Müller cells | Rat | 500 μM | (X Zhang et al., 2012) |
| Müller glial cell line MIO-M1 | Human | 250 μM | (Ahmad et al., 2021) |
| Müller glial cell line MIO-M1 | Human | 300 μM | (Abu El-Asrar et al., 2021) |
| Müller glial cell line MIO-M1 | Human | 75 μM - 500 μM | (Subirada et al., 2022) |
| Retina | Mouse | 200 μM | (Y Wang et al., 2017) |
| Retina | Porcine | 300 μM | (Mueller-Buehl et al., 2021 ; Tsai et al., 2020) |
| Retinal endothelial cells (HRECs) | Human | 200 μM | (Long et al., 2019) |
| Retinal Ganglion Cell (RGC) - Primary | Rat | 100 μM | (Youale et al., 2022) |
| Retinal microvascular endothelial cells (HRMECs) | Human | 300 μM | (Abu El-Asrar et al., 2022) |
| Retinal Müller glial cells | Human | 300 μM | (Abu El-Asrar et al., 2022) |
| Retinal pigmented epithelial cells (RPE) | Human | 100 μM | (Ma et al., 2012) |
| Retinal pigmented epithelial cells (RPE) | Human | 100 – 350 μM | (Alivand et al., 2016; Alivand et al., 2017) |
| Retinal pigmented epithelial cells (RPE) | Human | 150 μM | (Hollborn et al., 2018; Rosen et al., 2015) |
| Retinal pigmented epithelial cells (RPE) | Human | 200 μM | (ZX Zhang et al., 2011) |
| Retinal pigmented epithelial cells (RPE) | Human | 8 mM, 12 mM | (Cheng et al., 2019) |
| Retinal pigmented epithelial cells (RPE) | Mouse | 200 μM | (YQ Wang et al., 2010) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 10 – 1000 μM | (Guerra et al., 2021) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 50 – 300 μM | (Y Wang et al., 2016) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 100 μM | (Du et al., 2013; Hwang et al., 2020; Sant et al., 2018) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 100 – 1000 μM | (Chang et al., 2017) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 150 μM | (Alzhrani et al., 2017; Lai et al., 2017; Veltmann et al., 2016) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 200 μM | (Bahrami et al., 2019; Ibuki et al., 2020 ; Kunimi et al., 2019; Shoda et al., 2020; Takei et al., 2017; H Zhang et al., 2020; Y Zhang et al., 2018; Zhao et al., 2015; Zhu et al., 2016) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 200 – 800 μM | (Gu et al., 2021) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 300 μM | (Zheng et al., 2016) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 600 μM | (Zhou et al., 2018) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 600 μM | (KR Li et al., 2013) |
| Retinal pigment epithelial (RPE) cell line ARPE-19 | Human | 8 mM | (Cheng et al., 2019) |
| Retinal pigment epithelial (RPE) cell line hTERT RPE1 | Human | 25 – 75 μg/mL | (Qiao et al., 2021) |
| Retinal pigment epithelial (RPE) cell line hTERT RPE1 | Human | 75 μg/mL | (Qiao et al., 2021) |
| Retinal Cell Line (R28) | Human | 0.5 mM | (Thakur et al., 2021) |
| Retinoblastoma cell lines (Y79 and Weri-Rb1) | Human | 50 – 400 μM | (Q Yang et al., 2017) |
| Retinoblastoma cell lines (Y79 and Weri-Rb1) | Human | 100 – 300 μM | (Sradhanjali et al., 2017) |