Table 1.
Bactericidal titers by vaccination status.
MenW isolate | MenACWY vaccine |
4CMenB vaccine |
||||
---|---|---|---|---|---|---|
Adolescents |
Adolescents |
Infants |
||||
Pre-immune | Post-immune | Pre-immune | Post-2nd dose | Control sera | Post-4th dose | |
ARG-2991 | <16 | 256 | <4 | <4 | <2 | <2 |
ARG-3006 | <16 | >512 | <4 | >128* | <2 | >64 |
ARG-3052 | <16 | 256 | <4 | >128 | 2 | >64† |
ARG-3064 | <16 | 256 | <4 | >128 | <2 | >64 |
ARG-3158 | <16 | >512 | <4 | 64* | <2 | >64 |
ARG-3200 | <16 | 256 | <4 | >128 | <2 | >64 |
ARG-3216 | <16 | 256 | <4 | >128 | <2 | >64* |
ARG-3223 | <16 | 256 | 4 | >128 | 2 | >64 |
ARG-3273 | <16 | >512 | <4 | >128* | <2 | >64* |
ARG-3279 | <16 | ≥512 | <4 | 64 | <2 | >64 |
ARG-3320 | <16 | ≥512 | <4 | >128* | <2 | >64 |
*Prozone effect: bacterial survival was observed at high antibody concentrations due to the prozone effect, which is often detected when there is an excess of antibodies.
†Bacteriostatic.
4CMenB, 4-component meningococcal serogroup B vaccine; ARG, Argentina; MenACWY, meningococcal serogroups A, C, W, and Y; MenW, meningococcal serogroup W.