Extended Data Fig. 5. Secondary Structure of the E.r. Group IIC Intron and Conservation of Protein and RNA Sequences.

a. Secondary structure diagram of the E.r. IIC intron. RNA domains are labelled D1-D6 (four subdomains of D1 are labelled as D1a, D1b, D1c and D1d respectively). Tertiary interactions are labelled with Greek letters. Exon binding sequences and intron binding sequences are labelled as EBS and IBS respectively. b. Sequence alignment of the D1c and D6 regions of bacterial group IIC introns. c. Sequence alignment of bacterial group IIC maturases. The regions involved in interactions with D6 within the thumb and DBD are shown under the arrows.