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. 2023 Oct 2;4(12):1648–1659. doi: 10.1038/s43018-023-00645-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a) Boxplots showing viability (AUC in single-drug conditions and VUC in daunorubicin + cytarabine combination) after ex vivo drug treatment for drugs with significantly different responses in responders and non-responders. P-values from two-sided Students t-tests. Responder: n = 47, Non-responder: n = 48. Center, hinges and whiskers of the boxplots signify median, quartiles and 1.5x IQR, respectively. (b) Dose response curves for corresponding single drug conditions. Dose-response curves were built by fitting a 5-parameter logistic model for each clinical response group using ex vivo viability measurements across five drug concentrations. Individual patient observations are displayed by circles. Error bars represent mean and 95% CI. Responder: n = 47, Non-responder: n = 48.

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