Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 23;4(12):1675–1692. doi: 10.1038/s43018-023-00656-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, Histograms of MFI on live HSCs (live Lin⁻CD34⁺CD45^dimCD90⁺CD38⁻) and lympho-primed MPP cells (LMPPs; live Lin⁻CD34⁺CD38⁻CD90⁻CD45RA⁺ cells) from normal bone marrow (blue lines) versus on AML leukemia stem cells (LSCs; live CD34⁺CD38⁻CD90⁻CD45RA⁺ cells) for five distinct patients with AML whose bulk leukemic cells express cell surface U5 snRNP200. b, Bubble plot summarizing surface antigen expression and mutation status patterns. Bubbles with dark circle outlines highlight patterns that reach statistical significance (that is, CD25 expression and DNMT3A mutations co-occur, whereas CD33 and RUNX1 mutations are mutually exclusive). log-transformed P values were determined by one-sided Fisher test, with positive values indicating positive associations and negative values indicating negative associations. c, Circos plot depicting coexpression between U5 snRNP200 and known AML-associated surface antigens on AML patient bone marrow blasts. d, Correlogram depicting Pearson correlation coefficients of surface antigen intensity on AML patient bone marrow blasts.

Source data