Table IV.

Plasma PK Parameters of the Different Drugs

	cyclophosphamide	quinidine	erlotinib	phenobarbital	colchicine	ribociclib	topotecan	cefadroxil	prexasertib	methotrexate
Dose (mg/kg)	130	40	50	10	1.5	100	4	36	10	1000
Route of administrationa	IP	IP	PO	IP	IV	PO	IV	IV	SC	IV
Empirical plasma PK models
fu, plasma	0,26	0,233	0,048	0,7	0,61	0,23	0,3	1	0,11	0,519
Central clearance (ml/min)	2.09	46.99	0.412	0.02	0.487	1.32	1.41	0.97	2.68	0.688
Intercompartmental clearance (ml/min)	0.086	0	0	0	2.11	0	0.486	0	0.276	0.03
Central compartment volume (ml)	18.53	2951.3	147	11.2	70.1	530.1	8.41	14	51.59	9.21
Peripheral compartment volume (ml)	1.77	0	0	0	705	0	18.36	0	97.47	2.14
1st order absorption (1/min)	0	2.61	0.012	0	0	0.046	0	0	0.018	0
Duration (min)	0	101	0	0	0	0	0	0	0	0
Interindividual variability (as variance)
Central clearance	0.012	0	0	0	0	0.217	0.011	0	0.046	0.021
Intercompartmental clearance	0	0	0	0	0	0	0	0	0.027	0
Central compartment volume	0	0	0	0	0	0	0	0	0	0
Peripheral compartment volume	0	0	0	0	0	0	0	0	0	0
1st order absorption	0	0	0.614	0	0	0.676	0	0	0.04	0
Residual unexplained variabilities (as variance)
Proportional error	0.058	0	0.212	0.005	0.0224	0.276	0.051	0	0.003	0.18
Additive error (ng/ml)	0	2.05	0	0	0	0	0	0	0	0

^aRoutes of administration: IV = intravenous and IP = intraperitoneal, PO = oral, SC = subcutaneous