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. 2023 Dec 20;14:8477. doi: 10.1038/s41467-023-44142-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Combined UMAP projection of Müller glia (MG) and progenitor neuron cells profiled using multiomic sequencing. Each point (cell) is colored by cell type (a) and time points (b). Resting (Rest); Activated (Act); MG-derived progenitor cells (MGPCs); amacrine cell (AC); retinal ganglion cell (RGC); bipolar cell (BC); precursor (pre). c UMAPs showing trajectories constructed from mutiomics datasets of combined light damage (LD) and NMDA datasets. Color indicates pseudotime state. d Line graphs showing the fraction of cells (x axis) at each time point (y axis) of each cell type. Lines are colored by treatment. The paired t-test were used to compare the cell fraction from LD and NMDA. p values are labeled at the bottom of the graph. e Heatmap shows the consensus marker genes and their related marker peaks (TSS and enhancer) between LD and NMDA treatment for each cell type. f Heatmap shows the consensus motifs between LD and NMDA treatment for each cell type. g Heatmap shows the differential genes and their related differential peaks (TSS and enhancer) between LD and NMDA treatment for MG (Rest), MG (Act) and MGPCs. h Heatmap shows the differential motifs between LD and NMDA treatment for MG (Rest), MG(Act), and MGPCs.