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. 2023 Dec 20;14:8461. doi: 10.1038/s41467-023-44312-w

Fig. 1. Potential intermediates of EndoMT are detected in postnatal bone marrow using scRNA-seq.

Fig. 1

a t-SNE visualization of EC and stromal cell clusters (n = 5554 ECs and stromal cells) in the scRNA-seq of collagenase-digested bone and bone marrow cells from 5-week-old wild-type mice (n = 3 mice). E ECs. L LEPR+ BMSCs. O osteolineage cells. C chondrolineage cells. S/P SMCs/PCs. b, c t-SNE diagrams showing the presence of endothelial and mesenchymal markers (b), and the Venn diagrams showing the co-expression of endothelial and mesenchymal markers (c) in ECs and stromal cell subtypes. d Boxplots showing the transcript levels of endothelial and mesenchymal markers in ECs and stromal cell subtypes expressing these markers (number of cells expressing endothelial/mesenchymal markers are shown in c). EM, endothelial marker. MM, mesenchymal markers. Boxplots display the following parameters: the median (middle line), the first and third quartiles (lower and upper edges of the “boxes”), the largest/smallest values no further than 1.5 times the distance between the first and third quartiles (upper/lower whiskers), data beyond the end of the whiskers (individually plotted dots), and the mean (small dots within “boxes”). Statistical significance was determined by two-tailed Wilcox rank-sum test. Source data are provided as a Source Data file.