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. 2023 Dec 20;14:8461. doi: 10.1038/s41467-023-44312-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The bone marrow cavity surrounding the cortical and trabecular bone is depicted. If ECs are a significant source of BMSCs, then large fractions of BMSCs should be marked by EC lineage tracing models Cdh5-rtTA-tetO-Cre and Tek-CreERT2, both of which effectively trace bone marrow ECs. Additionally, BMSCs derived from ECs should be similarly marked by the two EC lineage tracing models. Moreover, subsets of ECs may express mesenchymal markers such as PRRX1 and LEPR. However, the observed results showed that only a minor fraction of BMSCs were Cdh5⁺ or Tek⁺. Additionally, Cdh5⁺ BMSCs and Tek⁺ BMSCs displayed different frequencies, spatial distribution and characteristic mesenchymal markers. Furthermore, Prrx1⁺ ECs and Lepr⁺ ECs were not present.