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. 2023 Dec 20;14:8491. doi: 10.1038/s41467-023-44176-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic of NOD.Cg-Prkdc^scidIl2rg^em1Smoc (NSG) (female, aged 8-12 weeks) model for (b–e). b Kaplan–Meier analysis of the mice survival in each experimental group (n = 8 animals in 2 batches). c Tumour burden (average radiance, ph/s) of mice treated with WT/IRU CAR-T cells (+/- CsA) (n = 8 animals in 2 batches). d Frequencies of CAR-T cells in bone marrow after tumour injection at day 7, 14 and 21 (n = 8 animals in two batches, 14 animals in three batches, and 7 animals in two batches at day 7, 14, and 21 respectively in WT CAR-T (-CsA); n = 8 animals in two batches, 24 animals in four batches and 8 animals in two batches at day 7, 14 and 21 respectively in WT CAR-T (+CsA); n = 8 animals in two batches, 15 animals in three batches and 8 animals in two batches at day 7, 14 and 21 respectively in IRU CAR-T (-CsA); n = 8 animals in two batches, 17 animals in four batches and 8 animals in two batches at day 7, 14 and 21 respectively in IRU CAR-T (+CsA)). e, f Cytokine detection of CAR-T cells in each group at day 14 upon stimulation with PMA/Ionomycin for 4 hrs. Donut (e) and column charts (f) indicated the proportion of CAR-T cells in each group that expressed cytokines (n = 8 animals in two batches in each group). All data are means±s.d. P values were determined by Mantel-Cox log-rank test (b) or Mann-Whitney test (d) or Multiple t test adjusted by the Holm-Sidak method (f). WT CAR-T (-CsA) as blue circle, WT CAR-T (+CsA) as blue square, IRU CAR-T (-CsA) as red circle, and IRU CAR-T (+CsA) as red square. Abbreviations: i.v. intravenous injection; i.p. intraperitoneal injection.