FIGURE 2.

Multi‐omics is useful for prioritization of GWAS‐significant genes. Genes that are proximal to a GWAS‐significant locus and are identified by multi‐omics methods in the smaller GWAS are likely to contain a GWAS‐significant locus in the larger GWAS. (A) The positive predictive value and sensitivity for each method, and for all methods combined (Any). ‘SNP‐only’ = the gene is proximal to a GWAS‐significant locus, but is not identified by multi‐omics. (B) Performance for increasing agreement between multi‐omics methods. (C) Performance of machine‐learning (ML) in the larger GWAS (ML was trained in the smaller GWAS). Points represent the estimates, while horizonal bars reflect the 95% CI. AUD/PAU = Alcohol use disorder/Problematic alcohol use; MDD/DEP = Major depressive disorder/Depression; SCZ = Schizophrenia; ICV/BV = Intracranial volume/Brain volume.