Table 1.
Demographic and cardiac characteristics of Egypt and UK HCM cohorts
| General characteristics | Egypt HCM | UK HCM | P-value |
|---|---|---|---|
| Demographics | |||
| Age (years) [mean (SD)] | 34.7 ± 17.4 | 55.5 ± 15.5 | <2.2 × 10−16 |
| Male sex | 345 (67.3%) | 473 (73.4%) | 0.02 |
| Offspring of consanguineous marriagea | 99 (28.4%) | N/A | N/A |
| FH of HCM | 111 (25.1%) | 127 (24.5%) | 0.88 |
| FH of SCD | 78 (17.6%) | 116 (25.2%) | 0.01 |
| Cardiac characteristics | |||
| LVMWT (mm)b [mean (SD)] | 23.6 ± 7 | 18.9 ± 4.4 | 4.9 × 10−15 |
| Extreme LVMWT >30 mm | 54 (17.5%) | 8 (1.3%) | <2.2 × 10−16 |
| LVOTO ≥30 mmHg | 220 (72.8%) | 223 (36.1%) | <2.2 × 10−16 |
| LVEF (%)b [mean (SD)] | 71.5 ± 13.3 | 74.3 ± 8.5 | 0.004 |
| Myectomy | 168 (51.5%) | N/A | N/A |
| ICD implantation | 7 (2.7%) | N/A | N/A |
HCM, hypertrophic cardiomyopathy; FH, family history; SCD, sudden cardiac death; LVMWT, left ventricular maximal wall thickness; LVOTO, left ventricular outflow tract obstruction; LVEF, left ventricular ejection fraction; ICD, implantable cardioverter-defibrillator; N/A, not available; SD, standard deviation.
aConsanguinity (self-reported) was defined as first-cousin marriage.
bLVMWT and LVEF were measured in the Egypt HCM and UK HCM cohorts by echocardiography and CMR, respectively.