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. 2023 Dec 15;5(4):290–306. doi: 10.1089/bioe.2022.0036

FIG. 7.

FIG. 7.

Potential model for ER calcium-mediated regulation of BMP/Dpp signaling. Together SERCA, Orai, Stim, SK, and Best2 help regulate the flux of ER calcium. Calcium movement out of the ER potentially through IP3R regulates calcium oscillations that in turn regulate the fusion of BMP/Dpp containing vesicles impacting downstream signaling.