Figure 2. Signaling pathway of nicotine improves memory function.

PDE-5, phosphodiesterase-5; HDAC, histone deacetylases; PD, Parkinson's disease; SIRT6, Sirtuin 6; LTP, long-term potentiation; p-CAMKII, phosphorylated calmodulin-dependent protein kinase II; TRβ, thyroid receptor subunit β; PI3K, phosphoinositide 3-kinase; AD, Alzheimer's disease; nAChR, nicotinic cholinergic receptors

[5]

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