Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 20;15:196. doi: 10.1186/s13148-023-01598-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — A–C Scatterplots for differentially methylated sites genome wide. Each point represents a probe of the 850 K array, and significantly differentially methylated probes (FDR < 0.05) are marked with red. Cluster 1A has the highest number of differentially methylated sites when compared to all other tumour samples (non-Cluster 1A) (B) or when compared only to Cluster 2 (C). D Top 10 gene set enrichment analysis (GSEA) results on differentially methylated promoters in Cluster 1A tumours after collapsing the redundant pathways with their corresponding gene-rank plots. Receptor tyrosine kinase and MAPK signalling pathways and the extracellular matrix are amongst the most affected. NES: normalised enrichment score. F: β-values of differentially methylated probes between metastatic and non-metastatic SDHB tumours. In the case of non-metastatic tumours, DMPs are in a binary state, mostly completely unmethylated with some completely methylated. In contrast, these loci in metastatic tumours have intermediate methylation levels. Mean ± standard deviation error bars