Table 4.

The inflammatory regulation of IFN-I signaling in the NF-κB pathway

Study	Types of IFN-I	Target of action	Stimuli	Experimental models	Effect	Diseases
Sermersheim et al. 2020 [178]	IFN-β	RYR and NF-κB	MG53	MG53 knockout mice	Anti-inflammatory	Not given
Lee et al. 2021 [179]	IFN-β	PKR and NF-κB	nc886	HEp-2 cells	Anti-inflammatory	Not given
Dong et al. 2023 [180]	IFN-α	PKA/CREB/NF-κB	A2AR	PI-IBS mouse models	Pro-inflammatory	PI-IBS
Zhang et al. 2019 [181]	IFN-β	TRAF 6	miR-146a	A549 cells	Anti-inflammatory	Viral infection
Chen et al. 2023 [182]	IFN-β	TRAF 6	USP47	Mouse peritoneal macrophages	Anti-inflammatory	Viral infection