Table 2.

Multinomial regression testing the association between use of epinephrine and outcomes

	Cardiocirculatory death		Neurological death		Other death
	aOR 95%CI	p value	aOR 95%CI	p value	aOR 95%CI	p value
Epinephrine during CPR
0 mg	Reference		Reference		Reference
1 mg  2–5 mg  > 5 mg	3.45 (2.01–5.92) 12.28 (7.52–20.06) 23.71 (11.02–50.97)	< 0.001  < 0.001  < 0.001	4.40 (2.79–6.94) 8.88 (5.80–13.59) 10.26 (4.94–21.31)	< 0.001  < 0.001  < 0.001	2.69 (1.49–4.85) 5.95 (3.49–10.13) 7.45 (3.20–17.33)	0.001  < 0.001  < 0.001

Reference population: alive at hospital discharge

Adjustment variables: gender, age, location, witnessed OHCA, bystander CPR, no-flow duration, initial electrical rhythm, low-flow duration, medical history: heart disease, cancer, renal disease, high blood pressure, ECMO use, coronary angioplasty intervention, TTM, post-resuscitation shock, presumed cardiac cause

aOR, adjusted odds ratio; 95%CI, 95% confidence interval; OHCA, out-of-hospital cardiac arrest; CPR, cardiopulmonary resuscitation; ECMO, extracorporeal membrane oxygenation; TTM, targeted temperature management