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. 2023 Dec 21;21:500. doi: 10.1186/s12951-023-02234-1

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Protective effects of C-dots on HIRI in vivo. (A) The diagram depicts the setup and plan for treating HIRI mice. (B) H&E staining was performed on liver tissues. Scale bar: 100 μm. (C) Liver tissues were subjected to TUNEL assay and Dihydroethidium (DHE) staining. Scale bar: 50 μm. (D) After various treatments, the levels of ALT and AST in the serum of HIRI mice were measured at 24 h. (E) The change in weight of HIRI mice 24 h after being administered with C-dots. Expression levels of mRNAs for cytokines of IL-1β (F), IL-6 (G), IL-12 (H), TNF-α (I) mRNA were comparatively analyzed