Table 2.
Multivariable Cox regression model including L_t0 and L_r1.
| Variables | Type of variable | HR | 95% CI | p Value |
|---|---|---|---|---|
| Age | Continuous | 0.72 | 0.52–0.99 | 0.0005 |
| ER primary | Continuous | 0.77 | 0.62–0.96 | 0.0499 |
| Ki–67 primary | Continuous | 1.10 | 0.95–1.28 | 0.1958 |
| No. metastatic sites | Continuous | 1.41 | 1.12–1.76 | 0.0029 |
| DFI | Continuous | 0.92 | 0.74–1.23 | 0.0042 |
| Line of treatment | Continuous | 1.19 | 1.09–1.29 | 0.0001 |
| ECOG PS | ||||
| 1 versus 0 | 1.63 | 1.27–2.09 | <0.0001 | |
| 2 versus 0 | 3.52 | 2.00–6.18 | ||
| Presence of liver metastases | Yes versus No | 1.54 | 1.20–1.99 | 0.0009 |
| L_t0 | Continuous | 0.78 | 0.66–0.92 | 0.0144 |
| L_r1 | Continuous | 0.82 | 0.73–0.93 | 0.0037 |
The p value is indicated in bold numbers when statistically significant (<0.05).
DFI, disease free interval; ECOG PS, Eastern Cooperative Oncology Group Performance Status; ER, estrogen receptor; L_t0, lymphocyte count at T0; L_r1, lymphocyte T1–T0 ratio.